This important study introduces a new biology-informed strategy for deep learning models aiming to predict mutational effects in antibody sequences. It provides solid evidence that separating ...

This study offers important insight into the pathogenic basis of intragenic frameshift deletions in the carboxy-terminal domain of MECP2, which account for some Rett syndrome cases, yet similar ...

The language of protein translation contains synonyms. Each three-nucleotide sequence on a strand of messenger RNA is called a codon and corresponds to the instruction to add a particular amino acid ...

Scientists trying to engineer biologic molecules with new functions have long felt limited by the 20 amino-acid building blocks. Researchers are working to develop ways of putting new building ...

It's a dogma taught in every introductory biology class: Proteins are composed of combinations of 20 different amino acids, arranged into diverse sequences like words. But researchers trying to ...

LA JOLLA, CA—It’s a dogma taught in every introductory biology class: Proteins are composed of combinations of 20 different amino acids, arranged into diverse sequences like words. But researchers ...

Although synonymous (or “silent”) variants have no effect on amino acid sequence, some synonymous variants influence fitness and susceptibility to disease. Mechanisms include interference with ...

In the early 1980s, Grantham and colleagues (Grantham et al., 1980a,b) proposed that the genome rather than the individual gene is the unit of codon usage selection and each genome seems to have its ...

Mauritania's Hamza Labeid (front) dives prior to the start of the heats of the men's 50-metre freestyle swimming event in the FINA World Championships at the indoor stadium of the Oriental Sports ...

Comparative analyses of natural and mutated sequences have been used to probe mechanisms of gene expression, but small sample sizes may produce biased outcomes. We applied an unbiased ...

The Best Genes, Well-Tailored Systems, and Ideal Growth Conditions Essential to Process The three most important things when expressing protein for high-throughput applications are: optimize, optimize ...