PALI-2108 is the first and only PDE4 inhibitor in development designed for targeted delivery to the terminal ileum and colon, addressing ...

In patients with Crohn’s Disease, achieving intestinal ultrasound transmural healing is linked to improved long-term outcomes ...

Background Intestinal fibrosis, a hallmark complication of Crohn’s disease (CD), frequently progresses to stricture formation and surgical intervention. Fibroblast metabolic reprogramming is important ...

What Is Crohn’s Constipation? You likely have constipation if it's hard for you to poop and you're having fewer bowel movements than you normally do. The same is true whether or not you have Crohn’s ...

Intestinal fibrosis is a common and serious complication of inflammatory bowel diseases, often leading to strictures that require endoscopic or surgical intervention. Despite advances in ...

Fat—adipose tissue—is more complicated than might be thought. Once considered just a bag of calories, scientists now know that fat doesn’t just squirrel away energy, it also sends and receives ...

Fat is more complicated than we thought. Once considered just a bag of calories, scientists now know that our fat — aka adipose tissue — doesn’t just squirrel away energy; it also sends and receives ...

Statins have been shown to have antifibrotic effects on various tissues and organs, but their ability to improve chronic colitis-associated intestinal fibrosis and their mechanisms of action remain ...

Describes the nature of a clinical study. Types include: Observational study — observes people and measures outcomes without affecting results. Interventional study (clinical trial) — studies new ...

Although a growing spectrum of biologic therapies have proven effective in managing inflammation and inflammatory strictures in Crohn's disease (CD), treatment options remain limited for fibrotic ...