“This review explores our current understanding of how ECM geometry influences the behaviors of both immune cells and tumor cells, which in turn impacts treatment efficacy and cancer evolutionary ...

CAFs in TME: key Immunosuppressors. Secreting CXCLs, ILs, TGF-β, CCL12, PGE2, CAFs promote pro-cancer macrophage conversion, inactivate NK cells, and hinder CD8+T cell aggregation. Immune cells like ...

Senescence. It’s a beautiful-sounding word whose tones suggest it should be a perfume or an essential oil. But that’s not ...

The numerous cells that make up mammalian tissues are surrounded by an intricate network of proteins known as the extracellular matrix (ECM). Together, these proteins provide cells with a structural ...

The tumor microenvironment (TME) is a complex and dynamic network consisting of tumor cells, immune cells, stromal cells, extracellular matrix (ECM), cytokines, and growth factors, all interacting to ...

With a growing number of exosome-based delivery vehicles advancing into the clinic for therapeutics and vaccines, more effective isolation and separation strategies are needed. Finnish researchers ...

Studying the spatial organization of all the cells in the niche or neighborhood of a tumor is crucial to fully understand how cancers progress. Since proximity speaks to cellular activity, the spatial ...

Researchers have shown that activation of the protein YAP, known to help cancer cells survive treatment, behaves very differently in cell culture models depending on how they are grown in the lab, ...