Abstract: Understanding cell-cell communication in cancer is important because cancer cells communicate to facilitate collective migration, such as during cancer progression and metastasis. We ...

One of the biggest quests in biology is understanding how every cell in an animal's body carries an identical genome yet still gives rise to a kaleidoscope of different cell types and tissues. A ...

Researchers from the Keck School of Medicine of USC have developed a new type of chimeric antigen receptor (CAR) T cell that elicits a more controlled immune response to cancer in mice—effectively ...

Here’s what you’ll learn when you read this story: With more than 100,000 people in need of an organ transplant in the U.S. alone, scientists have turned toward perfecting human-animal chimeras as a ...

Recent works in mechanobiology have investigated overarching changes in cell behavior in response to extracellular matrix (ECM) stiffness. Nonetheless, little is known about how key metabolic pathways ...

Introduction: The extracellular matrix (ECM) stiffness serves as a critical biomechanical regulator of cellular behavior. However, its specific roles on lymphatic endothelial cells (LECs) remains ...

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. Fibrotic processes involve aberrant deposition of extracellular matrix and contribute ...

This paper explores the role of extracellular vesicles in providing extracellular matrix signals for migration of vascular smooth muscle cells. The evidence, based on cell culture experiments and ...

Background: Estrogen can inhibit the apoptosis of nucleus pulposus cells (NPCs) through the PI3K/AKT/mTOR signaling pathway. However, the downstream of mTOR signaling pathway remains elusive. This ...

New research from scientists at the Karolinska Institutet in Sweden and their collaborators elsewhere describes a way of improving extracellular vesicles’ ability to transport things like therapeutic ...

Professor Suzannah Williams wishes she didn’t have to spend her days analyzing poop samples. It’s a dirty job; but someone’s got to do it. Biodiversity is rapidly dwindling, with wildlife populations ...