A community cohort boasting 16,000 participants? A memory clinic that sees more than 2,000 patients per month? A countrywide goal of screening 80 percent of its aged population for AD? These are a few ...
According to a recent study, the view that Alzheimer’s disease damages the brain irreversibly might need to change. In December 22 Cell Reports Medicine online, scientists led by Andrew Pieper of Case ...
When TDP-43 escapes from the nucleus, cells bungle mRNA processing, chopping up and splicing transcripts in the wrong places. Most studies have focused on retention of “cryptic” exons, but recent work ...
The App SAA mouse joins a list of knock-in models that carry a humanized Aβ sequence within the murine App gene (App knock-in (humanized Aβ), APP NL-F Knock-in, APP NL-G-F Knock-in). As in the latter ...
Phosphorylated tau isn’t just pathological junk; it helps the brain defend against viral infections. So claim scientists led by Rudolph Tanzi and William Eimer at Massachusetts General Hospital in ...
Brain Donation Autopsy Program Baylor College of Medicine, Department of Neurology 6501 Fannin St., NB320 Houston, TXTexas 77030 United States Visit Website Contact: Dr. Suzanne Powell, ADMDC ...
Dozens of rodents have been generated that model various aspects of ALS, like motor impairment or degeneration of motor neurons. No model recapitulates the human disease perfectly. By organizing ...
A documentary of country legend Glen Campbell's life and “Goodbye Tour” following his diagnosis of Alzheimer's.
A single-center pilot study at the Veterans Affairs Hospital/University of Washington in Seattle reported improved verbal memory retention and attention after a three-week test of 20 international ...
The dbl-PAC-Tg(SNCA A53T) +/+;Snca-/-model, referred to here as double-transgenic mice, are mice lacking endogenous α-synuclein (Snca knockout mice) that were crossed with two homozygous transgenic ...
This database is a repository of normal genetic variability, designed to be a tool for researchers who study neurodegenerative disease. It contains whole-exome sequencing results from nearly 500 ...
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