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Deep learning–based codon optimization framework boosts protein expression in E coli

By combining Transformer-based sequence modeling with a novel conditional probability strategy, the approach overcomes ...

Uncovering a secret room that a giant virus creates inside its host amoeba

A virus relies on the host's translation machinery to replicate itself and become infectious. Translation efficiency ...
eLife

Separating selection from mutation in antibody language models

This important study introduces a new biology-informed strategy for deep learning models aiming to predict mutational effects in antibody sequences. It provides solid evidence that separating ...