The poly(ADP-ribose) polymerase (PARP) family of proteins use NAD + as their substrate to modify acceptor proteins with ADP-ribose modifications. The function of most PARPs under physiological ...
The FDA has already approved PARP inhibitors in certain patients with metastatic castration-resistant prostate cancer (mCRPC). Now, Johnson & Johnson’s Akeega is giving the class a win in ...
PARP inhibitors are a type of cancer drug. PARP stands for poly adenosine diphosphate-ribose polymerase, a type of enzyme that helps repair DNA damage in cells. PARP inhibitors work by preventing ...
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