Cells use several different mechanisms to ensure the fidelity of gene expression, including processes that monitor the integrity of RNA synthesis and processing, transfer RNA aminoacylation, peptide ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 112, No. 10 (March 10, 2015), pp. 3038-3043 (6 pages) Premature termination codons (PTCs) in an mRNA ORF ...

Nonsense-mediated mRNA decay (NMD) is a translation-dependent mechanism of RNA decay that probably evolved to eliminate abnormal transcripts that are a consequence of routine abnormalities in gene ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 69, No. 10 (Oct., 1972), pp. 3014-3018 (5 pages) The tritiated trinucleotide UGA was used in a binding assay to ...

With their latest discovery, researchers have significantly advanced the understanding of how human cells protect themselves from constant and potentially destructive changes in gene expression.

Between 10 to 15% of all genetic diseases have the same underlying cause: a nonsense mutation. 1 This type of mutation results from a stop codon in the middle of a gene sequence, which terminates ...

On the surface, cystic fibrosis and Tay-Sachs disease have nothing in common. Although both are inherited genetic disorders, one causes thick mucus buildup in the lungs, making it progressively harder ...

With their latest discovery, researchers have significantly advanced the understanding of how human cells protect themselves from constant and potentially destructive changes in gene expression. With ...