In their recent article in Journal of Clinical Oncology, Soni et al 1 compared findings from randomized controlled trials (RCTs) in oncology with analogous observational comparative effectiveness ...

OBJECTIVE To assess the effectiveness of hydroxychloroquine in patients admitted to hospital with coronavirus disease 2019 (covid-19) pneumonia who require oxygen. DESIGN Comparative observational ...

M.J.S. and D.E.S. contributed equally to this work. Comparative efficacy research performed using population registries can be subject to significant bias. There is an absence of objective data ...

Please provide your email address to receive an email when new articles are posted on . Studies using observational data to compare drug effectiveness must report the proportion of patients who stop ...

A research-driven evaluation assessing the comparative effectiveness of phosphodiesterase type 5 (PDE5) inhibitors is contributing to ongoing clinical discourse around vascular-mediated functional ...

The evidence assessed by the external assessment centre (EAC) included 19 studies, all of which were full-text peer-reviewed publications. Of the included studies, 9 were comparative studies (3 ...

Patients with ABI require prolonged mechanical ventilation and have a substantially higher risk for VAP due to impaired airway protection and injury-related immune dysfunction. However, routine use of ...

Major uncertainties remain about the impact of puberty blockers and gender affirming hormone therapy on children and young people with gender related distress (gender dysphoria), making it impossible ...

NICE commissioned an external assessment centre (EAC) to review the evidence submitted by the company. This section summarises that review. Full details of all the evidence are in the project ...