Little is currently known about the molecular determinants of energy barriers along enzyme catalytic pathways. Kern and co-workers have studied this question in adenylate kinase (Adk) and now reveal ...

The serine proteinase plasmin is the key fibrinolytic enzyme that dissolves blood clots and also promotes cell migration and tissue remodeling. Here, we report the 2.65 Å crystal structure of a ...

Researchers have identified a molecule sent by fat cells to the fly brain that senses when they have had enough food and inhibits feeding. Researchers have identified a molecule sent by fat cells to ...

A team has discovered how hydrogen-producing enzymes, called hydrogenases, are activated during their biosynthesis. They showed how the cofactor -- part of the active center and also the heart of the ...

Assembly of nitrogenase FeMoco is one of the key processes in bioinorganic chemistry. NifB and NifEN are two essential elements immediately adjacent to each other along the biosynthetic pathway of ...

“Enzyme cascades” are important for biocatalytic transformations in biological cells. These processes involve complex networks and take place in spatially confined microenvironments. A team of ...

Enzymes are generally globular proteins and range from just 62 amino acid residues in size, for the monomer of 4 oxalocrotonate tautomerase,[12] to over 2 fake ray bans,500 residues in the animal ...

A team from Ruhr-Universität Bochum and the University of Oxford has discovered how hydrogen-producing enzymes, called hydrogenases, are activated during their biosynthesis. They showed how the ...