The extracellular matrix (ECM) is a dynamic scaffold that governs tissue integrity, cellular behavior, and organ function through its biomechanical and biochemical properties. Emerging research ...

The numerous cells that make up mammalian tissues are surrounded by an intricate network of proteins known as the extracellular matrix (ECM). Together, these proteins provide cells with a structural ...

CAFs in TME: key Immunosuppressors. Secreting CXCLs, ILs, TGF-β, CCL12, PGE2, CAFs promote pro-cancer macrophage conversion, inactivate NK cells, and hinder CD8+T cell aggregation. Immune cells like ...

Senescence. It’s a beautiful-sounding word whose tones suggest it should be a perfume or an essential oil. But that’s not ...

NSCLC cells sense mechanical forces from their surroundings through a dense, fibrous network of collagen called the extracellular matrix. The increased environmental rigidity can force YAP into the ...

The tumor microenvironment (TME) is a complex and dynamic network consisting of tumor cells, immune cells, stromal cells, extracellular matrix (ECM), cytokines, and growth factors, all interacting to ...

Mechano-Growth Factor (MGF), often referred to as the IGF-1 Ec isoform (or IGF-1 Eb), is a splice variant of the insulin-like ...

Studying the spatial organization of all the cells in the niche or neighborhood of a tumor is crucial to fully understand how cancers progress. Since proximity speaks to cellular activity, the spatial ...

Gene therapy is a promising technique for the treatment of a wide range of diseases at the genetic level, addressing the root cause of many subsequent disorders. Recent advancements have facilitated ...

Researchers have shown that activation of the protein YAP, known to help cancer cells survive treatment, behaves very differently in cell culture models depending on how they are grown in the lab, ...