UPTON, NY -- By deciphering the near atomic-level structure of the catalytic domain of botulinum toxin type E -- one of seven neurotoxins that cause botulism, a disease that paralyzes victims by ...

Several bacteria from the Clostridium genus produce botulinum neurotoxins—the most potent biological toxins known—that cause botulism by blocking neurotransmitter release from nerves. Typically, the ...

Scientists have determined the structure of a third subtype of botulinum neurotoxin -- a deadly toxin that causes the disease botulism, and is also used in cosmetic and therapeutic applications. The ...

The toxin complex with its 14 components. The toxin itself is colored pink and sits at the top of the complex. The structure consists of tens of thousands of atoms, and here we only show the surface ...

Two research groups have designed chimeric fusion proteins that constitute a new “trojan horse” approach to neutralize lethal botulinum toxins. Botulinum neurotoxins (BoNTs)—a family of bacterial ...